The -E version of the F-15 is reportedly dual-role, both air-to-air and air-to-ground. But has only been used as a ground attack aircraft except for one other air-to-air incident in Iraq in 1991 when it took out an Iraqi MI-24 helicopter, but that was done with air to ground ordnance, GBU-10. Unclear so far as to whether the Shahed-129 was taken out by 20mm gun, AIM-9 or AIM-120. The F-15 design is over 30 years old now. There have been upgrades, but the average age is 26 years and the average airframe had 6000 hours flying time five years ago, probably closer to 7000 hours now.
https://theaviationist.com/2017/06/09/u-s-f-15e-downs-iranian-built-syrian-drone-after-airstrike-on-u-s-led-forces/
http://www.af.mil/About-Us/Fact-Sheets/Display/Article/104499/f-15e-strike-eagle/